LIBD Schizophrenia DLPFC Differential Expression Browser

We performed differential expression analysis on 155 cases with schizophrenia and 196 unaffected adult controls, adjusting for observed clinical and technical covariates (age, sex, RNA quality) and additional latent variables related to ethnicity (genomic principal components) and RNA quality ( quality surrogate variables) across five transcript feature summarization. We further assessed replication in the CommonMind Consortium using analogous statistical models. Additional details are available at Jaffe et al, bioRxiv 2017.