BrainSeq Phase 1

Schizophrenia DLPFC

Data Browser Links

Processed Data

These are RangedSummarizedExperiment R Objects

These are regular RData objects:

Processed Results

SCZD vs Control: All Quantified Features, RData
SCZD vs Control: All Expressed Features, RData
eQTL: All Significant (~29M) eQTLs, RData. This needs a lot of memory.
Developmental Changes, Table S3, CSV

Raw Data

RNA-seq reads: FASTQ via Synapse.org
Phenotype data: CSV via GitHub, RData via GitHub
Genotype data: dbGaP - we will share analysis-ready genotype data with researchers that obtain dbGaP access of that accession.

This site describes data and resources for the BrainSeq Phase1 DLPFC resource paper

Jaffe AE, Straub RE, Shin JH, Tao R, Gao Y, Collado-Torres L, Kam-Thong T, Xi HS, Quan J, Chen Q, Colantuoni C, Ulrich B, Maher BJ, Deep-Soboslay A, The BrainSeq Consortium, Cross A, Brandon NJ, Leek JT, Hyde TM, Kleinman JE, Weinberger DR. Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis. Nat Neuro, 2018. In Press.

Analysis code is available on GitHub